KKU Research Journal
ISSN 0859-3957

շ 19 Ѻ 6+ January - February 2015

Synthesis and Rat Prostate 5-Alpha Reductase Inhibitions of Methylated Quercetin Derivatives

Youngrong Park, Yong-ung Kim and Jaehong Han*

 

Metalloenzyme Research Group and Department of Systems Biotechnology, Chung-Ang University, Anseong, 456-756, Korea

Department of Pharmaceutical Engineering, College of Herbal Bio-industry, Daegu Haany University, Gyeongsan, 712-715, Korea

* Correspondent author:jaehongh@cau.ac.kr

 

Abstract

Interested in chemical and biological properties of polymethoxyflavones, a series of methylated quercetin derivatives were synthesized and characterized. Quercetin was methylated with CH 3 I in the presence of K 2 CO 3 /DMF, and the products were purified by column chromatography. Three quercetin derivatives with different methyl group numbers were isolated and the chemical structures were confirmed by IR and NMR. Along with physical characterizations, rat prostate steroid 5?-reductase inhibition of the quercetin derivatives was measured. It was found that methylation of quercetin lowered the inhibitory effect of the derivatives against 5?-reductase.

 

Keywords : polymethoxyflavones, quercetin derivatives, steroid 5-alpha reductase





 

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